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Impurity analysis of retinoic acid samples.

Allegrone G, Brenna E, Fronza G, Fuganti C, Giovenzana T, Malpezzi L, Barlocchi E, Pellegatta C

Dip. Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Univ. Degli Studi del Piemonte Orientale A.Avogadro, Novara, Italy.

The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.

Published 8 July 2005 in Bioorg Med Chem Lett, 15(15): 3528-31.
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